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Additionally, sulfated chitosan (SCS) induces neutrophil apoptosis and promotes M2 macrophage polarization via the IL-10/STAT3 pathway, shortening the acute inflammatory phase and facilitating tissue repair (251) Thus, post-stroke remodeling of microglial/macrophage polarization—through activating specific receptor pathways such as FPR2/ALX and PPARγ, regulating metabolic programs like cholesterol sulfate synthesis, and modulating immune cell crosstalk—constitutes a critical strategy for mitigating secondary injury and promoting neural recovery

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(2022) Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring

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